Microcalorimetry of Macromolecules: The Physical Basis of Biological Structures

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Siminovitch, and R. With permission from American Chemical Society Click here to view. Other Lipid Classes. Reprinted by permission from Proc. Mabrey and J. Figure 7 :DSC scans of a A. Drug Purity. Drug Stability. Antimicrobial Peptides. Prenner, R. Lewis, L. Kondejewski, R. Hodges, R. McElhaney, Differential scanning calorimetric study of the effect of the antimicrobial peptide gramicidin S on the thermotropic phase behavior of phosphatidylcholine, phosphatidylethanolamine and phosphatidylglycerol lipid bilayer membranes, , , with permission from Elsevier[] Click here to view.

McElhaney RN.

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The use of differential scanning calorimetry and differential thermal analysis in studies of model and biological membranes. Chem Phys Lipids ; Freire E. Differential scanning calorimetry. Methods Mol Biol ; Microcalorimetry of biological macromolecules. Biophys Chem ; Sturtevant J. Biochemical applications of differential scanning calorimetry. Ann Rev Phys Chem ; Jelesarov I, Bosshard HR. Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energies of biomolecular recognition. J Mol Recognit ; Applications of scanning microcalorimetry in biophysics and biochemistry.

X-Ray Diffraction in Biology: How Can We See DNA and Proteins in Three Dimensions?

Thermochim Acta ; Differential scanning calorimetric studies of lipid-protein interactions in model membrane systems. Biochim Biophys Acta ; Privalov P, Plotnikov V. Three generations of scanning microcalorimeters for liquids. Precise scanning calorimeter for studying thermal properties of biological macromolecules in dilute solution. Anal Biochem ; Biltonen RL, Lichtenberg D. The use of differential scanning calorimetry as a tool to characterize liposome preparations.

Department of Biology

Applications of calorimetric methods to drug discovery and the study of protein interactions. Curr Opin Struct Biol ; Problems and Prospects in microcalorimetry of biological macromolecules. Methods Enzymol ; An autosampling differential scanning calorimeter instrument for studying molecular interactions. Assay Drug Dev Tech ; Giron D. Applications of thermal analysis and coupled techniques in pharmaceutical.

J Thermal Anal Calorim ; Vyazovkin S. Thermal analysis. Anal Chem ; Demetzos C. Differential Scanning Calorimetry DSC : A tool to study the thermal behavior of lipid bilayers and liposome stability. J Liposome Res ; Differential Scanning Calorimetry. Methods in Cell Biology. Amsterdam: Academic Press; Statistical thermodynamic analysis of differential scanning calorimetry data - structural deconvolution of heat-capacity function of proteins.

Numerical Computer Methods, Pt B.

Microcalorimetry by Wojciech Swietoslawski | | Booktopia

San Diego: Academic Press Inc; Chen T, Oakley DM. Thermal-analysis of proteins of pharmaceutical interest. Sturtevant JM. Effects of mutations on thermodynamic properties of proteins. Acs Symp Ser ; Cooper M. Label-free screening of bio-molecular interactions. Anal Bioanal Chem ; Fisher HF, Singh N. Calorimetric methods for interpreting protein-ligand interactions. Energetics of Biological Macromolecules.

Measurements of binding thermodynamics in drug discovery. Drug Discov Today ; Energetics of membrane protein folding and stability. Arch Biochem Biophys ; Thermal denaturation methods in the study of protein folding. Eftink MR. Use of multiple spectroscopic methods to monitor equilibrium unfolding of proteins. Wunderlich B. Thermal analysis of macromolecules - A personal review. J Therm Anal ; Membrane lipid molecular structure and polymorphism, Lipid Polymorphism and Membrane Properties.

Phase behavior of membranes containing bioactive lipids, Lipid Polymorphism and Membrane Properties. Drug-Membrane interactions: Significance for medicinal chemistry. Curr Med Chem ; Mouritsen OG, Bloom M. Differential scanning calorimetry: Applications in drug development. Pharma Sci Technol Today ; Contribution of thermal methods and related techniques to the rational development of pharmaceuticals-Part 1.

Buckton G, Beezer AE. The applications of Microcalorimetry in the Field of Physical Pharmacy. Int J Pharma ; Thermodynamics of partly folded intermediates in proteins. Annu Rev Biophys Biomolecul Struct ; Scanning microcalorimetry in studying temperature-induced changes in proteins.

Sanchez-Ruiz JM. Protein Kinetic Stability. Freire E, Biltonen RL. Statistical mechanical deconvolution of thermal transitions in macromolecules I. Theory and applications to homogeneous systems. Biopolymers ; Differential scanning calorimetry of proteins. Subcell Biochem ; Biltonen RL, Freire E. Thermodynamic characterization of conformational states of macromolecules using differential scanning calorimetry.

Castronuovo G. Proteins in aqueous solutions - calorimetric studies and thermodynamic characterization. Jaenicke R. Stability and folding of domain proteins. Prog Biophys Mol Biol ; Amorphous pharmaceutical solids: Preparation, characterization and stabilization. Adv Drug Deliv Rev ; Ligand effects on protein thermodynamic stability. Mechanisms of Protein Stabilization in the Solid State. J Pharma Sci ; Analytical techniques for the evaluation of liquid protein therapeutics.

Biotechnol Appl Biochem ; Problems and prospects in microcalorimetry of biological macromolecules. Pt C, Vol. Differential scanning calorimetry in life science: Thermodynamics, Stability, Molecular recognition and application in drug design. Calorimetric and spectroscopic studies of the interaction of manduca-sexta apolipophorin-III with zwitterionic anionic and nonionic lipids.

Biochemistry ; Apolipophorin III interaction with model membranes composed of phosphatidylcholine and sphingomyelin using differential scanning calorimetry. Biochim Biophys Acta-Biomembr ; Haltia T, Freire E. Forces and factors that contribute to the structural stability of membrane-proteins.

heymidamomi.ga Perez-Gil J. Fetal Pediatr Pathol ; Research activities in this multidisciplinary group concentrate on the energetics and mechanism of fundamental processes in biological macromolecules and living systems, utilising sensitive biophysical instrumentation coupled with advanced molecular biology techniques. Much of this work is in close collaboration with colleagues from other disciplines.

Topics include:. Froth, Foam and Bubble: The biophysical chemistry and potential applications of foamy biological secretions. A Sir Henry Wellcome Commemorative project in collaboration with Malcolm Kennedy , also funded in part by BBSRC, allowed us to initiate studies into the macromolecular structure and properties of foam nests of tropical frogs.

Student & Faculty Resources

Heat Denaturation of Proteins 7. Reversibility of Heat Denaturation 7. Cooperativity of Denaturation 7. Heat Capacity of the Native and Denatured States 7. Functions Specifying Protein Stability 7. Cold Denaturation 7. Proteins at Low Temperatures 7. Experimental Observation of Cold Denaturation 7. Isothermal pH Titration of Globular Proteins 7.

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Denaturant-Induced Protein Unfolding 7. Use of Denaturants for Estimating Protein Stability 7. Calorimetric Studies of Protein Unfolding by Denaturants 7. Unfolded State of Protein 7.

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  4. Completeness of Protein Unfolding at Denaturation 7. Thermodynamic Functions Describing Protein States 8. Energetic Basis of Protein Structure 8. Hydration Effects 8. Proteins in an Aqueous Environment 8. Hydration of Protein Groups 8. Hydration of the Folded and Unfolded Protein 8. Protein in Vacuum 8.

    Heat Capacity of Globular Proteins 8. Enthalpy of Protein Unfolding in Vacuum 8. Entropy of Protein Unfolding in Vacuum 8. Back into the Water 8.

    Biological Molecules

    Enthalpies of Protein Unfolding in Water 8. Hydrogen Bonds 8. Hydrophobic Effect 8. Protein Folding 9. Macrostabilities and Microstabilities of Protein Structure 9. Macrostability of Proteins 9. Microstability of Proteins 9. Packing in Protein Interior 9. Protein Folding Technology 9. Intermediate States in Protein Folding 9.

    Molten Globule Concept 9. Formation of Protein Structure 9. Transient State in Protein Folding 9. Mechanism of Cooperation 9. Thermodynamic States of Proteins Multidomain Proteins Criterion of Cooperativity Deviations from a Two-State Unfolding-Refolding Papain Pepsinogen Proteins with Internal Homology Evolution of Multidomain Proteins Ovomucoid Calcium-Binding Proteins Plasminogen Fibrinogen Fibronectin Discreteness in Protein Structure Macromolecular Complexes Entropy of Association Reactions Thermodynamics of Molecular Association Experimental Verification of the Translational Entropy Calorimetry of Association Entropy SSI Dimer Dissociation Dissociation of the Coiled-Coil Entropy Cost of Association Thermodynamics of Molecular Recognition Calorimetry of Protein Complex Formation Target Peptide Recognition by Calmodulin Thermodynamic Analysis of Macromolecular Complexes Protein-DNA Interaction Problems Two Approaches Homeodomains IRF Transcription Factors AT-Hooks HMG Boxes Minor versus Major Groove Binding Concluding Remarks Nucleic Acids DNA Polynucleotides Melting of Polynucleotides Calorimetry of Poly A -Poly U Short DNA Duplexes Cost of DNA Bending RNA